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SB 203186 hydrochloride

CAS No. 207572-69-8

SB 203186 hydrochloride( —— )

Catalog No. M23932 CAS No. 207572-69-8

SB 203186 hydrochloride is a potent 5-HT4 receptor antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 50 In Stock
10MG 87 In Stock
25MG 178 In Stock
50MG 295 In Stock
100MG 441 In Stock
500MG 972 In Stock
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Biological Information

  • Product Name
    SB 203186 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    SB 203186 hydrochloride is a potent 5-HT4 receptor antagonist.
  • Description
    SB 203186 hydrochloride is a potent 5-HT4 receptor antagonist.
  • In Vitro
    Pretreatment with SB-203186 (10 μM) enhances the 5-HT-induced contractions of the antral strips.
  • In Vivo
    Intraduodenally administered SB-203186 (0.3-3 mg/kg) to new-born Camborough piglets produced blockade of 5-HT-evoked tachycardia which was maximal after 20 min and lasted for more than 3 h with 0.3 mg/kg.SB-203186 (0.1-3mg/kg, i.v.) surmountably antagonised 5-HT-evoked tachycardia in anaesthetized Yucatan minipigs or new-born Camborough piglets with similar potency.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    207572-69-8
  • Formula Weight
    308.81
  • Molecular Formula
    C16H20N2O2·HCl
  • Purity
    >98% (HPLC)
  • Solubility
    H2O:100 mM
  • SMILES
    O=C(C1=CNC2=C1C=CC=C2)OCCN3CCCCC3.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Parker S G , Taylor E M , Hamburger S A , et al. Blockade of human and porcine myocardial 5-HT4 receptors by SB 203186[J]. Naunyn Schmiedebergs Arch Pharmacol, 1995, 353(1):28-35.
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