Cart
sales@molnova.com
SB 203186 hydrochloride
CAS No. 207572-69-8
SB 203186 hydrochloride( —— )
Catalog No. M23932 CAS No. 207572-69-8
SB 203186 hydrochloride is a potent 5-HT4 receptor antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 31 | In Stock |
|
| 5MG | 50 | In Stock |
|
| 10MG | 87 | In Stock |
|
| 25MG | 178 | In Stock |
|
| 50MG | 295 | In Stock |
|
| 100MG | 441 | In Stock |
|
| 500MG | 972 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSB 203186 hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionSB 203186 hydrochloride is a potent 5-HT4 receptor antagonist.
-
DescriptionSB 203186 hydrochloride is a potent 5-HT4 receptor antagonist.
-
In VitroPretreatment with SB-203186 (10 μM) enhances the 5-HT-induced contractions of the antral strips.
-
In VivoIntraduodenally administered SB-203186 (0.3-3 mg/kg) to new-born Camborough piglets produced blockade of 5-HT-evoked tachycardia which was maximal after 20 min and lasted for more than 3 h with 0.3 mg/kg.SB-203186 (0.1-3mg/kg, i.v.) surmountably antagonised 5-HT-evoked tachycardia in anaesthetized Yucatan minipigs or new-born Camborough piglets with similar potency.
-
Synonyms——
-
PathwayEndocrinology/Hormones
-
Target5-HT Receptor
-
Recptor5-HT4
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number207572-69-8
-
Formula Weight308.81
-
Molecular FormulaC16H20N2O2·HCl
-
Purity>98% (HPLC)
-
SolubilityH2O:100 mM
-
SMILESO=C(C1=CNC2=C1C=CC=C2)OCCN3CCCCC3.Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Parker S G , Taylor E M , Hamburger S A , et al. Blockade of human and porcine myocardial 5-HT4 receptors by SB 203186[J]. Naunyn Schmiedebergs Arch Pharmacol, 1995, 353(1):28-35.
molnova catalog
related products
-
AVN-101 hydrochlorid...
AVN-101 is a very potent 5-HT7 receptor antagonist (Ki = 153 pM). AVN-101 also exhibits a rather high affinity toward histamine H1 (Ki = 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki = 0.41-3.6 nM) receptors.
-
Blonanserin
Blonanserin is a novel atypical antipsychotic agent with potent dopamine D2 and serotonin 5-HT2 receptors antagonist properties.
-
Strictosidinic acid
Strictosidinic acid, an orally active glycoside indole monoterpene alkaloid isolated from Psychotria myriantha leaves, inhibits precursor enzymes of 5-HT biosynthesis and reduces the 5-HT levels.
