SB 203186 hydrochloride

CAS No. 207572-69-8

SB 203186 hydrochloride( —— )

Catalog No. M23932 CAS No. 207572-69-8

SB 203186 hydrochloride is a potent 5-HT4 receptor antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 31 In Stock
5MG 50 In Stock
10MG 87 In Stock
25MG 178 In Stock
50MG 295 In Stock
100MG 441 In Stock
500MG 972 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    SB 203186 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    SB 203186 hydrochloride is a potent 5-HT4 receptor antagonist.
  • Description
    SB 203186 hydrochloride is a potent 5-HT4 receptor antagonist.
  • In Vitro
    Pretreatment with SB-203186 (10 μM) enhances the 5-HT-induced contractions of the antral strips.
  • In Vivo
    Intraduodenally administered SB-203186 (0.3-3 mg/kg) to new-born Camborough piglets produced blockade of 5-HT-evoked tachycardia which was maximal after 20 min and lasted for more than 3 h with 0.3 mg/kg.SB-203186 (0.1-3mg/kg, i.v.) surmountably antagonised 5-HT-evoked tachycardia in anaesthetized Yucatan minipigs or new-born Camborough piglets with similar potency.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    207572-69-8
  • Formula Weight
    308.81
  • Molecular Formula
    C16H20N2O2·HCl
  • Purity
    >98% (HPLC)
  • Solubility
    H2O:100 mM
  • SMILES
    O=C(C1=CNC2=C1C=CC=C2)OCCN3CCCCC3.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Parker S G , Taylor E M , Hamburger S A , et al. Blockade of human and porcine myocardial 5-HT4 receptors by SB 203186[J]. Naunyn Schmiedebergs Arch Pharmacol, 1995, 353(1):28-35.
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